Searchable abstracts of presentations at key conferences in endocrinology

ea0032p601 | Female reproduction | ECE2013

Flutamide-induced alterations in CYP17A1 gene expression and local testosterone synthesis in porcine luteal tissue – a new insight into androgens action during pregnancy

Grzesiak Malgorzata , Knapczyk-Stwora Katarzyna , Wieciech Iwona , Ciereszko Renata E , Slomczynska Maria

It was established that androgens are able to modulate luteal function during pregnancy by stimulation of corpus luteum (CL) progesterone release. In pigs, CL is the main source of progesterone through the entire gestation. Our previous study revealed that porcine CL is capable of androgen synthesis during second half of pregnancy. Therefore, we suggest that androgens, in addition to progesterone, are essential for the maintenance of pregnancy in pigs.Th...